Welcome to the ENACT Network!

ENACT builds upon the CTSA Consortium cohort discovery platform, ACT, to enable investigators and trainees at CTSA hubs to conduct EHR-based research on any disease or condition across the network of over 142M patients.

ENACT was developed collaboratively by members of NCATS’ Clinical and Translational Science Award (CTSA) consortium, with funding from the NIH National Center for Advancing Translational Sciences.

What can you expect with ENACT?

  • The largest federated network for EHR-based research with access to 142M de-identified patients
  • Ability for researchers at participating CTSA hubs to efficiently conduct regulatory-compliant EHR research on their desktop
  • Build out of the ACT ontology and a launch of new data quality initiatives
  • Access to trainees for educational purposes
  • Support for the application of AI and machine learning to large-scale EHR data
  • Encouragement for informatics experts to develop and validate new EHR-based research tools
HIPAA and IRB Information: Usage of the ENACT Network is approved by the IRB at each member institution, and complies with HIPAA requirements for patient confidentiality. 
Learn More >

How-To Resources

Access tutorials to learn the nuts and bolts of using ENACT.

Learn More


Review answers to commonly asked questions about ENACT.

Get Answers

Technical Resources

Learn about further resources.

Learn More

Get To

Learn more about the sites and data available through ENACT.

Learn More


Coming Soon!

Governance &
Regulatory Info

Find out more about how ENACT is governed, how it works with local IRBs, and how to cite ENACT in your work.

Find Out